The herpes simplex virus VP16-induced complex: the makings of a regulatory switch

Wysocka, J., Herr, W. (June 2003) The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Trends in Biochemical Sciences, 28 (6). pp. 294-304. ISSN 09680004 (ISSN)

DOI: 10.1016/S0968-0004(03)00088-4


When herpes simplex virus (HSV) infects human cells, it is able to enter two modes of infection: lytic and latent. A key activator of lytic infection is a virion protein called VP16, which, upon infection of a permissive cell, forms a transcriptional regulatory complex with two cellular proteins - the POU-domain transcription factor Oct-1 and the cell-proliferation factor HCF-1 - to activate transcription of the first set of expressed viral genes. This regulatory complex, called the VP16-induced complex, reveals mechanisms of combinatorial control of transcription. The activities of Oct-1 and HCF-1 - two important regulators of cellular gene expression and proliferation - illuminate strategies by which HSV might coexist with its host.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Division DNA-Binding Proteins/ metabolism Gene Expression Regulation Herpes Simplex Virus Protein Vmw65/chemistry/ physiology Host Cell Factor C1 Octamer Transcription Factor-1 Proteins/ metabolism Simplexvirus/ metabolism Transcription Factors/ metabolism Transcription, Genetic
Subjects: organism description > virus > herpes simplex virus
organism description > virus
CSHL Authors:
Communities: CSHL labs > Herr lab
Depositing User: Matt Covey
Date: June 2003
Date Deposited: 26 Jun 2013 19:24
Last Modified: 26 Jun 2013 19:24
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