Wysocka, J., Herr, W. (June 2003) The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Trends in Biochemical Sciences, 28 (6). pp. 294-304. ISSN 09680004 (ISSN)
Abstract
When herpes simplex virus (HSV) infects human cells, it is able to enter two modes of infection: lytic and latent. A key activator of lytic infection is a virion protein called VP16, which, upon infection of a permissive cell, forms a transcriptional regulatory complex with two cellular proteins - the POU-domain transcription factor Oct-1 and the cell-proliferation factor HCF-1 - to activate transcription of the first set of expressed viral genes. This regulatory complex, called the VP16-induced complex, reveals mechanisms of combinatorial control of transcription. The activities of Oct-1 and HCF-1 - two important regulators of cellular gene expression and proliferation - illuminate strategies by which HSV might coexist with its host.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Cell Division DNA-Binding Proteins/ metabolism Gene Expression Regulation Herpes Simplex Virus Protein Vmw65/chemistry/ physiology Host Cell Factor C1 Octamer Transcription Factor-1 Proteins/ metabolism Simplexvirus/ metabolism Transcription Factors/ metabolism Transcription, Genetic |
| Subjects: | organism description > virus > herpes simplex virus organism description > virus |
| CSHL Authors: | |
| Communities: | CSHL labs > Herr lab |
| Depositing User: | Matt Covey |
| Date: | June 2003 |
| Date Deposited: | 26 Jun 2013 19:24 |
| Last Modified: | 26 Jun 2013 19:24 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27947 |
Actions (login required)
 |
Administrator's edit/view item |