Hendricks, J. C., Lu, S. M., Kume, K., Yin, J. C. P., Yang, Z. H., Sehgal, A. (February 2003) Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. Journal of Biological Rhythms, 18 (1). pp. 12-25. ISSN 0748-7304
Abstract
The central clock is generally thought to provide timing information for rest/activity but not to otherwise participate in regulation of these states. To test the hypothesis that genes that are components of the molecular clock also regulate rest, the authors quantified the duration and intensity of consolidated rest and activity for the four viable Drosophila mutations of the central clock that lead to arrhythmic locomotor behavior and for the pdf mutant that lacks pigment-dispersing factor, an output neuropeptide. Only the cycle (cyc(01)) and Clock (Clk(lrk)) mutants had abnormalities that mapped to the mutant locus, namely, decreased consolidated rest and grossly extended periods of activity. All mutants with the exception of the cyc(01) fly exhibited a qualitatively normal compensatory rebound after rest deprivation. This abnormal response in cyc(01) was sexually dimorphic, being reduced or absent in males and exaggerated in females. Finally, the cyc(01) mutation shortened the life span of male flies. These data indicate that cycle regulates rest and life span in male Drosophila.
| Item Type: | Paper |
|---|---|
| Additional Information: | ISI Document Delivery No.: 639LK Times Cited: 21 Cited Reference Count: 43 |
| Uncontrolled Keywords: | Drosophila sleep-like rest gender dimorphism steep regulation longevity BMAL1 QUANTITATIVE TRAIT LOCI CIRCADIAN PACEMAKER LIFE-SPAN CLOCK GENES SLEEP PERIOD TRANSCRIPTION TIMELESS RHYTHMS NEURONS |
| Subjects: | organism description > animal > insect > Drosophila organs, tissues, organelles, cell types and functions > tissues types and functions > biological clock organism description > animal > gender organism description > animal > insect |
| CSHL Authors: | |
| Communities: | CSHL labs > Yin lab |
| Depositing User: | Matt Covey |
| Date: | February 2003 |
| Date Deposited: | 01 Jul 2013 20:05 |
| Last Modified: | 01 Jul 2013 20:05 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27880 |
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