Esteban, J. A., Shi, S. H., Wilson, C., Nuriya, M., Huganir, R. L., Malinow, R.
(February 2003)
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity.
Nature Neuroscience, 6 (2).
pp. 136-143.
ISSN 1097-6256
Abstract
The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation of the AMPA receptor subunits GluR4 and GluR1 directly controlled the synaptic incorporation of AMPA receptors in organotypic slices from rat hippocampus. Activity-driven PKA phosphorylation of GluR4 was necessary and sufficient to relieve a retention interaction and drive receptors into synapses. In contrast, PKA phosphorylation of GluR1 and the activity of calcium/calmodulin-dependent kinase II (CaMKII) were both necessary for receptor incorporation. Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
LONG-TERM POTENTIATION
DEPENDENT PROTEIN-KINASE
CYCLIC-AMP
FREQUENCY
STIMULATION
ACTIVATION INCREASES
HIPPOCAMPAL SYNAPSES
GLUTAMATE
RECEPTORS
LATE-PHASE
AREA CA1
LTP |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > phosphorylation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Malinow lab |
| Depositing User: |
Matt Covey
|
| Date: |
February 2003 |
| Date Deposited: |
01 Jul 2013 19:28 |
| Last Modified: |
01 Jul 2013 19:28 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/27874 |
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