Almagro, S., Dimitrov, S., Hirano, T., Vallade, M., Riveline, D.
(September 2003)
Individual chromosomes as viscoelastic copolymers.
Europhysics Letters, 63 (6).
pp. 908-914.
ISSN 0295-5075
Abstract
We report elastic measurements of individual chromosomes observed in vitro. Free fluctuations of shapes show that a chromosome can be seen as a copolymer, exhibiting rigid regions alternating with semi-flexible regions. We characterize this behavior and compare it with known biopolymers. We further show that the inner part of a chromosome exhibits viscoelasticity, as extracted by the loading rate dependence of the stretch modulus. Taken together, these data suggest an organization for the chromosome as a copolymer composed of an inner rigid core exhibiting viscoelasticity surrounded by an elastic soft envelope.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
MITOTIC CHROMOSOMES
DNA
ELASTICITY
MOLECULES
PROTEIN
FORCE
TITIN
CONDENSATION
NUCLEOSOMES
TRANSITIONS |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hirano lab |
| Depositing User: |
Matt Covey
|
| Date: |
September 2003 |
| Date Deposited: |
08 Jul 2013 20:54 |
| Last Modified: |
08 Jul 2013 20:54 |
| URI: |
https://repository.cshl.edu/id/eprint/27847 |
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