Strick, T. R., Dessinges, M. N., Charvin, G., Dekker, N. H., Allemand, J. F., Bensimon, D., Croquette, V. (January 2003) Stretching of macromolecules and proteins. Reports on Progress in Physics, 66 (1). pp. 1-45. ISSN 0034-4885
Abstract
In this paper we review the biophysics revealed by stretching single biopolymers. During the last decade various techniques have emerged allowing micromanipulation of single molecules and simultaneous measurements of their elasticity. Using such techniques, it has been possible to investigate some of the interactions playing a role in biology. We shall first review the simplest case of a non-interacting polymer and then present the structural transitions in DNA, RNA and proteins that have been studied by single-molecule techniques. We shall explain how these techniques permit a new approach to the protein folding/unfolding transition.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | ATOMIC-FORCE MICROSCOPY DOUBLE-STRANDED DNA SUPERCOILED DNA SINGLE-MOLECULE DOUBLE HELIX CONFORMATIONAL FLUCTUATIONS STRUCTURAL TRANSITIONS COMPLEMENTARY STRANDS ENTROPIC ELASTICITY PICONEWTON FORCES |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification |
| CSHL Authors: | |
| Communities: | CSHL labs > Strick lab |
| Depositing User: | Matt Covey |
| Date: | January 2003 |
| Date Deposited: | 08 Jul 2013 20:49 |
| Last Modified: | 08 Jul 2013 20:49 |
| URI: | https://repository.cshl.edu/id/eprint/27846 |
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