Kani, K., Sordella, R., Mallick, P.
(2012)
Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays.
Methods in Molecular Biology, 795.
pp. 233-53.
ISSN 1940-6029 (Electronic)1064-3745 (Linking)
Abstract
Clinical tools to accurately describe, evaluate, and predict an individual's response to cancer therapy are a field-wide priority; in many advanced cancers, only 10-20% of individuals will have a clinical benefit from therapy, yet we treat the entire population. Furthermore, many therapies are initially effective, but lose effectiveness over time. Here we describe methods to derive in vitro models of resistance to EGFR tyrosine kinase inhibitors. We additionally describe approaches to characterize possible mechanisms of resistance by genomic and transcriptomic approaches.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Antineoplastic Agents/ pharmacology/therapeutic use
Carcinoma, Non-Small-Cell Lung/drug therapy/ genetics
Cell Line, Tumor
Drug Resistance, Neoplasm/drug effects/genetics
Epithelial-Mesenchymal Transition/genetics
Gene Expression Profiling
Genetic Markers/genetics
Humans
Lung Neoplasms/drug therapy/ genetics
Oligonucleotide Array Sequence Analysis
Protein Kinase Inhibitors/ pharmacology/therapeutic use
Quinazolines/pharmacology
Receptor, Epidermal Growth Factor/antagonists & inhibitors/ genetics
Sequence Analysis, DNA |
| Subjects: |
bioinformatics > genomics and proteomics > analysis and processing
diseases & disorders > cancer
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > analysis and processing > microarray gene expression processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
therapies
therapies > cancer drugs - see diseases-cancer-drugs and therapies
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > epidermal growth factor
diseases & disorders > cancer > cancer types > lung cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
diseases & disorders > cancer > cancer types |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Sordella lab
CSHL Cancer Center Program > Signal Transduction |
| Depositing User: |
Matt Covey
|
| Date: |
2012 |
| Date Deposited: |
13 Mar 2013 14:40 |
| Last Modified: |
16 Oct 2015 14:07 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/27785 |
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