Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression

Ende, G., Demirakca, T., Walter, S., Wokrina, T., Sartorius, A., Wildgruber, D., Henn, F. A. (February 2007) Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression. Eur Arch Psychiatry Clin Neurosci, 257 (1). pp. 36-9. ISSN 0940-1334 (Print)0940-1334 (Linking)

DOI: 10.1007/s00406-006-0680-4


The purpose of the present study was to determine whether MR-detectable alterations of choline-containing compounds in two key neural systems involved in major depression disorder namely the hippocampus and the basal ganglia can be detected. Multislice proton magnetic resonance spectroscopic imaging was applied in 11 patients with major depressive disorder (MDD) and ten matched healthy subjects. Voxels were selected from the left and right side of the hippocampus and the putamen. Significantly lower choline-containing compounds in the hippocampus and significantly higher choline-containing compounds in the putamen of patients with MDD compared to healthy subjects were found. No significant differences were found for the other metabolites in the two regions evaluated. Abnormal levels of choline-containing compounds most likely reflect altered membrane phospholipid metabolism. A reduced level in the hippocampus and an increased level in the putamen suggest regionally opponent membrane abnormalities.

Item Type: Paper
Uncontrolled Keywords: Adult Aspartic Acid/analogs & derivatives/pharmacology Brain Chemistry Cell Membrane/metabolism Cerebral Cortex/metabolism/ pathology Creatine/metabolism Depressive Disorder, Major/metabolism/ pathology Energy Metabolism/physiology Female Humans Magnetic Resonance Imaging Male Myelin Sheath/metabolism Phosphocreatine/metabolism Psychiatric Status Rating Scales Putamen/metabolism Temporal Lobe/metabolism/ pathology
Subjects: diseases & disorders
Investigative techniques and equipment
diseases & disorders > mental disorders
diseases & disorders > mental disorders > mood disorders
diseases & disorders > mental disorders > mood disorders > depression
Investigative techniques and equipment > magnetic resonance imaging
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: February 2007
Date Deposited: 01 Mar 2013 14:06
Last Modified: 01 Mar 2013 14:06
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