Par complex in cancer: a regulator of normal cell polarity joins the dark side

Aranda, V., Nolan, M. E., Muthuswamy, S. K. (November 2008) Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene, 27 (55). pp. 6878-87.

URL: http://www.ncbi.nlm.nih.gov/pubmed/19029931
DOI: 10.1038/onc.2008.340

Abstract

In the past 20 years, the discovery and characterization of the molecular machinery that controls cellular polarization have enabled us to achieve a better understanding of many biological processes. Spatial asymmetry or establishment of cell polarity during embryogenesis, epithelial morphogenesis, neuronal differentiation, and migration of fibroblasts and T cells are thought to rely on a small number of evolutionarily conserved proteins and pathways. Correct polarization is crucial for normal cell physiology and tissue homeostasis, and is lost in cancer. Thus, cell polarity signaling is likely to have an important function in tumor progression. Recent findings have identified a regulator of cell polarity, the Par complex, as an important signaling node in tumorigenesis. In normal cell types, the Par complex is part of the molecular machinery that regulates cell polarity and maintains normal cell homeostasis. As such, the polarity regulators are proposed to have a tumor suppressor function, consistent with the loss of polarity genes associated with hyperproliferation in Drosophila melanogaster. However, recent studies showing that some members of this complex also display pro-oncogenic activities suggest a more complex regulation of the polarity machinery during cellular transformation. Here, we examine the existing data about the different functions of the Par complex. We discuss how spatial restriction, binding partners and substrate specificity determine the signaling properties of Par complex proteins. A better understanding of these processes will very likely shed some light on how the Par complex can switch from a normal polarity regulation function to promotion of transformation downstream of oncogenes.

Item Type: Paper
Uncontrolled Keywords: polarity cancer ErbB2 Par6 aPKC
Subjects: diseases & disorders > cancer
diseases & disorders
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell polarity
organs, tissues, organelles, cell types and functions > cell types and functions
organs, tissues, organelles, cell types and functions
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: Matt Covey
Date: 24 November 2008
Date Deposited: 25 Feb 2013 21:56
Last Modified: 25 Feb 2013 21:56
PMCID: PMC3017320
Related URLs:
URI: https://repository.cshl.edu/id/eprint/27589

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