G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm?

Boivin, B., Vaniotis, G., Allen, B. G., Hebert, T. E. (January 2008) G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm? J Recept Signal Transduct Res, 28 (1-2). pp. 15-28.

URL: http://www.ncbi.nlm.nih.gov/pubmed/18437627

DOI: 10.1080/10799890801941889

Abstract

Signaling from internalizing and endosomal receptors has almost become a classic GPCR paradigm in the last several years. However, it has become clear in recent years that GPCRs also elicit signals when resident at other subcellular sites including the endoplasmic reticulum, Golgi apparatus, and the nucleus. In this review we discuss the nature, function, and trafficking of nuclear GPCR signaling complexes, as well as potential sources of endogenous and exogenous ligands. Finally, we pose a series of questions that will need to be answered in the coming years to confirm and extend this as a new paradigm for GPCR signaling.

Item Type:	Paper
Uncontrolled Keywords:	Nuclear GPCRs Transcriptional regulation Receptor trafficking
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein organs, tissues, organelles, cell types and functions > organelles, types and functions > nucleus organs, tissues, organelles, cell types and functions > organelles, types and functions organs, tissues, organelles, cell types and functions bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein receptor bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:	Boivin, Benoit
Communities:	CSHL labs > Tonks lab
Depositing User:	Matt Covey
Date:	January 2008
Date Deposited:	26 Feb 2013 20:42
Last Modified:	26 Feb 2013 20:42
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27528

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