Pattern formation via small RNA mobility

Chitwood, D. H., Nogueira, F. T. S., Howell, M. D., Montgomery, T. A., Carrington, J. C., Timmermans, M. C. P. (March 2009) Pattern formation via small RNA mobility. Genes Dev, 23 (5). pp. 549-554. ISSN 0890-9369

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URL: http://www.ncbi.nlm.nih.gov/pubmed/19270155

DOI: 10.1101/gad.1770009

Abstract

MicroRNAs and trans-acting siRNAs (ta-siRNAs) have important regulatory roles in development. Unlike other developmentally important regulatory molecules, small RNAs are not known to act as mobile signals during development. Here, we show that low-abundant, conserved ta-siRNAs, termed tasiR-ARFs, move intercellularly from their defined source of biogenesis on the upper (adaxial) side of leaves to the lower (abaxial) side to create a gradient of small RNAs that patterns the abaxial determinant AUXIN RESPONSE FACTOR3. Our observations have important ramifications for the function of small RNAs and suggest they can serve as mobile, instructive signals during development.

Item Type:	Paper
Uncontrolled Keywords:	Small RNA miRNA Arabidopsis leaf polarity pattern fomation TRANS-ACTING SIRNAS EMBRYONIC-DEVELOPMENT MEDIATED REPRESSION LEAF POLARITY ARABIDOPSIS BIOGENESIS MICRORNAS EXPRESSION TARGETS PLANTS
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > sRNA
CSHL Authors:	Chitwood, Daniel H. Nogueira, Fabio T. S. Timmermans, Marja C. P.
Communities:	CSHL labs > Timmermans lab School of Biological Sciences > Publications
Depositing User:	Matt Covey
Date:	March 2009
Date Deposited:	20 Feb 2013 16:41
Last Modified:	03 Nov 2017 20:15
PMCID:	PMC2658522
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27430

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