Bolduc, F. V., Tully, T. (January 2009) Fruit flies and intellectual disability. Fly, 3 (1). pp. 91-104. ISSN 1933-6934
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Abstract
Mental retardation-known more commonly nowadays as intellectual disability-is a severe neurological condition affecting up to 3% of the general population. As a result of the analysis of familial cases and recent advances in clinical genetic testing, great strides have been made in our understanding of the genetic etiologies of mental retardation. Nonetheless, no treatment is currently clinically available to patients suffering from intellectual disability. Several animal models have been used in the study of memory and cognition. Established paradigms in Drosophila have recently captured cognitive defects in fly mutants for orthologs of genes involved in human intellectual disability. We review here three protocols designed to understand the molecular genetic basis of learning and memory in Drosophila and the genes identified so far with relation to mental retardation. In addition, we explore the mental retardation genes for which evidence of neuronal dysfunction other than memory has been established in Drosophila. Finally, we summarize the findings in Drosophila for mental retardation genes for which no neuronal information is yet available. All in all, this review illustrates the impressive overlap between genes identified in human mental retardation and genes involved in physiological learning and memory.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Drosophila mental retardation neurological disorders genetics development treatment FRAGILE-X-SYNDROME LONG-TERM-MEMORY LINKED MENTAL-RETARDATION COMPARATIVE GENOMIC HYBRIDIZATION DROSOPHILA MUSHROOM BODY SINGLE-MINDED GENE DE-LANGE-SYNDROME GLOBAL DEVELOPMENTAL DELAY AMPA RECEPTOR TRAFFICKING RUBINSTEIN-TAYBI-SYNDROME |
| Subjects: | organism description > animal > insect > Drosophila organism description > animal diseases & disorders > congenital hereditary genetic diseases > mental retardation |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | January 2009 |
| Date Deposited: | 20 Feb 2013 22:21 |
| Last Modified: | 22 Sep 2014 16:53 |
| PMCID: | PMC3045854 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27381 |
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