Control of cell adhesion dynamics by Rap1 signaling

Boettner, B., Van Aelst, L. (October 2009) Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol, 21 (5). 684-693 .

Abstract

Individual cells in their particular environments adhere to the extracellular matrix (ECM) and their neighbours via integrin-containing and cadherin-containing complexes, respectively. The dynamics of these interactions regulate the formation and maintenance of complex tissues. An expanding body of evidence accentuates the role of the small Rap1 GTPase and its associated signaling network in many of these processes. In this review we will discuss more recently revealed roles of Rap1 signaling by primarily focusing on functions of the Rap1 effectors RIAM, KRIT-1/CCM1 and AF-6/Afadin in junctional regulation of the vascular system and in epithelial cells. Furthermore, we will describe novel findings on the Rap activator PDZ-GEF in the regulation of cell-cell adhesion between epithelial cells and within a stem cell niche.

Item Type:	Paper
Uncontrolled Keywords:	Animals Cell Adhesion Gap Junctions/metabolism Guanine Nucleotide Exchange Factors/metabolism Humans Signal Transduction rap1 GTP-Binding Proteins/ metabolism
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > epithelial cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > epithelial cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > epithelial cell bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTP binding protein bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > matrix protein organs, tissues, organelles, cell types and functions bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:	Boettner, Benjamin Van Aelst, Linda
Communities:	CSHL labs > Van Aelst lab
Depositing User:	Matt Covey
Date:	October 2009
Date Deposited:	21 Feb 2013 21:14
Last Modified:	21 Feb 2013 21:14
PMCID:	PMC2841981
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27349

Actions (login required)

Administrator's edit/view item