Watson, J. D. (November 2011) Curing "incurable" Cancer. Cancer Discovery, 1 (6). pp. 477-480. ISSN 2159-8274
Abstract
Cancer cells are preferentially killed by anticancer agents because key signals for growth and cell division are "always on" as opposed to the alternative "on" and "off" signaling of normal cells. Too much of today's anticancer drug discovery effort may go toward reversing genetically promoted "always on" signals. More effective anticancer drug targets may be found through use of RNAi technologies that pinpoint the key gene regulatory and metabolic weakness of the "always on" cancer cells. Cancer Discovery; 1(6); 477-80. (C) 2011 AACR.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | met protooncogene tumor suppression growth pathway inhibition resistance mechanisms metformin therapy cells |
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification diseases & disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi therapies therapies > cancer drugs - see diseases-cancer-drugs and therapies |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | November 2011 |
| Date Deposited: | 05 Feb 2013 20:47 |
| Last Modified: | 05 Feb 2013 20:47 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27214 |
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