Rebbeck, C. A., Leroi, A. M., Burt, A. (January 2011) Mitochondrial capture by a transmissible cancer. Science, 331 (6015). p. 303.
Abstract
anine transmissible venereal tumor (CTVT) is an infectious cell line circulating in many feral dog populations. It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders organs, tissues, organelles, cell types and functions > organelles, types and functions > mitochondria organs, tissues, organelles, cell types and functions > organelles, types and functions organs, tissues, organelles, cell types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab CSHL Post Doctoral Fellows |
| Depositing User: | Matt Covey |
| Date: | January 2011 |
| Date Deposited: | 06 Feb 2013 14:44 |
| Last Modified: | 03 May 2013 14:02 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27193 |
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