3D culture reveals a signaling network

Muthuswamy, S. K. (2011) 3D culture reveals a signaling network. Breast Cancer Research, 13 (1). ISSN 1465-542X

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URL: http://www.ncbi.nlm.nih.gov/pubmed/21349209

Abstract

The behavior of a cell is significantly influenced by its context. Epithelial cells derived from glandular organs such as the breast recreate their glandular organization when grown under 3D culture conditions. While traditional monolayer cultures are powerful tools to understand how cells proliferate, grow and respond to stress, they do not recreate the 3D property observed in vivo. Multiple studies demonstrate that 3D organization can reveal novel and unexpected insights into the mechanisms by which normal and tumor-derived epithelial cells function. In the present article we comment on a study that reports identification of a RasV12-induced IL-6 signaling network in mammary epithelial cells in 3D cultures.

Item Type:	Paper
Uncontrolled Keywords:	transformation tumorigenesis cells stat3
Subjects:	diseases & disorders > cancer diseases & disorders diseases & disorders > cancer > cancer types > breast cancer organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > epithelial cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > epithelial cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > epithelial cell organs, tissues, organelles, cell types and functions diseases & disorders > cancer > cancer types
CSHL Authors:	Muthuswamy, Senthil K.
Communities:	CSHL labs > Muthuswamy lab
Depositing User:	Matt Covey
Date:	2011
Date Deposited:	06 Feb 2013 19:27
Last Modified:	06 Feb 2013 19:27
PMCID:	PMC3109562
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27181

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