Trastuzumab resistance: all roads lead to SRC

Muthuswamy, S. K. (April 2011) Trastuzumab resistance: all roads lead to SRC. Nature Medicine, 17 (4). pp. 416-8. ISSN 1078-8956

URL: http://www.ncbi.nlm.nih.gov/pubmed/21475230

DOI: 10.1038/nm0411-416

Abstract

A new study shows how SRC, a nonmembrane tyrosine kinase, is a common signaling node in trastuzumab resistance caused by different mechanisms in HER2-positive breast cancers (pages 461–469). A SRC inhibitor restored trastuzumab sensitivity in vitro and in mouse tumor models, suggesting a new way to tackle drug resistance in breast tumors.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders therapies diseases & disorders > cancer > cancer types > breast cancer therapies > cancer drugs - see diseases-cancer-drugs and therapies diseases & disorders > cancer > cancer types
CSHL Authors:	Muthuswamy, Senthil K.
Communities:	CSHL labs > Muthuswamy lab
Depositing User:	Matt Covey
Date:	April 2011
Date Deposited:	06 Feb 2013 19:24
Last Modified:	06 Feb 2013 19:24
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27180

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