Insight into the heterogeneity of breast cancer through next-generation sequencing

Russnes, H. G., Navin, N., Hicks, J. B., Borresen-Dale, A. L. (October 2011) Insight into the heterogeneity of breast cancer through next-generation sequencing. Journal of Clinical Investigation, 121 (10). pp. 3810-3818. ISSN 0021-9738

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DOI: 10.1172/jci57088


Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.

Item Type: Paper
Uncontrolled Keywords: comparative genomic hybridization gene-expression patterns bone-marrow micrometastasis tumor heterogeneity molecular subtypes single cells esophageal adenocarcinoma karyotypic comparisons clonal heterogeneity intrinsic subtypes
Subjects: diseases & disorders > cancer
diseases & disorders
Investigative techniques and equipment
Investigative techniques and equipment > assays
diseases & disorders > cancer > cancer types > breast cancer
diseases & disorders > cancer > cancer types
Investigative techniques and equipment > whole exome sequencing
Investigative techniques and equipment > assays > whole exome sequencing
CSHL Authors:
Communities: CSHL labs > Hicks lab
Depositing User: Matt Covey
Date: October 2011
Date Deposited: 06 Feb 2013 21:49
Last Modified: 06 Feb 2013 21:49
PMCID: PMC3195464
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