Russnes, H. G., Navin, N., Hicks, J. B., Borresen-Dale, A. L. (October 2011) Insight into the heterogeneity of breast cancer through next-generation sequencing. Journal of Clinical Investigation, 121 (10). pp. 3810-3818. ISSN 0021-9738
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Abstract
Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | comparative genomic hybridization gene-expression patterns bone-marrow micrometastasis tumor heterogeneity molecular subtypes single cells esophageal adenocarcinoma karyotypic comparisons clonal heterogeneity intrinsic subtypes |
| Subjects: | diseases & disorders > cancer diseases & disorders Investigative techniques and equipment Investigative techniques and equipment > assays diseases & disorders > cancer > cancer types > breast cancer diseases & disorders > cancer > cancer types Investigative techniques and equipment > whole exome sequencing Investigative techniques and equipment > assays > whole exome sequencing |
| CSHL Authors: | |
| Communities: | CSHL labs > Hicks lab |
| Depositing User: | Matt Covey |
| Date: | October 2011 |
| Date Deposited: | 06 Feb 2013 21:49 |
| Last Modified: | 06 Feb 2013 21:49 |
| PMCID: | PMC3195464 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27135 |
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