Muthuswamy, S. K., Xue, B. (August 2012) Cell Polarity as a Regulator of Cancer Cell Behavior Plasticity. Annu Rev Cell Dev Biol, 28 (28). pp. 599-625. ISSN 1530-8995 (Electronic)1081-0706 (Linking)
Abstract
Cell polarization is an evolutionarily conserved process that facilitates asymmetric distribution of organelles and proteins and that is modified dynamically during physiological processes such as cell division, migration, and morphogenesis. The plasticity with which cells change their behavior and phenotype in response to cell intrinsic and extrinsic cues is an essential feature of normal physiology. In disease states such as cancer, cells lose their ability to behave normally in response to physiological cues. A molecular understanding of mechanisms that alter the behavior of cancer cells is limited. Cell polarity proteins are a recognized class of molecules that can receive and interpret both intrinsic and extrinsic signals to modulate cell behavior. In this review, we discuss how cell polarity proteins regulate a diverse array of biological processes and how they can contribute to alterations in the behavior of cancer cells. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 28 is October 06, 2012. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell polarity organs, tissues, organelles, cell types and functions > cell types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Muthuswamy lab |
| Depositing User: | Matt Covey |
| Date: | 6 August 2012 |
| Date Deposited: | 30 Jan 2013 16:35 |
| Last Modified: | 20 Jul 2021 13:39 |
| PMCID: | PMC3997262 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27009 |
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