Systems memory consolidation in Drosophila

Dubnau, J., Chiang, A. S. (2013) Systems memory consolidation in Drosophila. Current Opinion in Neurobiology, 23 (1). pp. 84-91. ISSN 0959-4388

DOI: 10.1016/j.conb.2012.09.006


From an information processing perspective, memories need to be acquired, encoded, stored, maintained and retrieved. As time passes after training, memories become less easily retrieved, but also become progressively more stable in the face of experimental perturbations. This process is referred to as consolidation. But the term has been used to describe two different biological processes whose relationship is poorly understood [1,2]. The first, which we refer to as biochemical consolidation, involves cell-signaling events within a neuron. The second, which we call systems consolidation, involves ongoing communication between brain regions or cell types. Although systems consolidation was first thought to be at play only in complex brains, a number of recent studies reveal its importance in Drosophila. The ease of cell type specific genetic manipulations in flies provides a unique opportunity to forge an integrated mechanistic understanding of biochemical and systems consolidation.

Item Type: Paper
Subjects: organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
organism description > animal > insect
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal
CSHL Authors:
Communities: CSHL labs > Dubnau lab
Depositing User: Matt Covey
Date: 2013
Date Deposited: 31 Jan 2013 17:29
Last Modified: 29 Mar 2013 12:53
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