Chromatin dynamics and gene positioning

Kumaran, R. I., Thakar, R., Spector, D. L. (2008) Chromatin dynamics and gene positioning. Cell, 132 (6). pp. 929-934. ISSN 1097-4172 (Electronic) 0092-8674 (Linking)

DOI: 10.1016/j.cell.2008.03.004


The mammalian cell nucleus provides a landscape where genes are regulated through their organization and association with freely diffusing proteins and nuclear domains. In many cases, specific genes are highly dynamic, and the principles governing their movements and interchromosomal interactions are currently under intensive study. Recent investigations have implicated actin and myosin in chromatin dynamics and gene expression. Here, we discuss our current understanding of the dynamics of the interphase genome and how it impacts nuclear organization and gene activity.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Nucleus Chromatin Chromosomes Gene Expression Regulation Humans Interphase
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date: 2008
Date Deposited: 10 Dec 2012 20:02
Last Modified: 28 Jan 2015 16:44
PMCID: PMC2898133
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