Lyon, Gholson J., Samar, Stephanie, Jummani, Rahil, Hirsch, Scott, Spirgel, Arie, Goldman, Rachel, Coffey, Barbara J. (2009) Aripiprazole in children and adolescents with Tourette's disorder: an open-label safety and tolerability study. Journal of Child and Adolescent Psychopharmacology, 19 (6). pp. 623-633. ISSN 1557-8992
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Abstract
The aim of this study was to conduct a prospective safety and tolerability study of aripiprazole for the treatment of tics in children and adolescents with Tourette's disorder (TD).Eleven subjects (10 males) with TD (age 9-19 years, mean 13.36, standard deviation [SD] 3.33) who did not respond or were unable to tolerate previous tic medication were treated with aripiprazole in an open-label, flexible-dosing study over 10 weeks. Tic severity was rated using the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impressions Scale for tics (CGI-Tics) at baseline and at follow-up.The mean (+/-SD) daily dose for aripiprazole was 4.5 +/- 3.0 mg. Mean (+/-SD) YGTSS Global Severity scores reduced from 61.82 +/- 13.49 at baseline to 33.73 +/- 15.18 at end point; mean YGTSS total tic scores reduced from 28.18 +/- 7.74 at baseline to 16.73 +/- 7.54 at end point. Mean (+/-SD) CGI-Tic severity scores reduced from 4.45 +/- 0.52 (moderate-marked) at baseline to 3.18 +/- 0.60 (mild) at end point. On the CGI-Tic improvement scale, 10 (91%) subjects achieved 1 ("very much improved") or 2 ("much improved") at end point. Most common adverse effects included appetite increase and weight gain in 5 subjects, mild extrapyramidal effects in 7 subjects, and headaches and tiredness/fatigue in 7 subjects; 1 subject experienced akathisia and muscle cramps.Aripiprazole appears to be a safe and tolerable treatment in children and adolescents with TD that appears to reduce tics; it should be further investigated as a treatment option in controlled trials.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adolescent Antipsychotic Agents Body Weight Child Dose-Response Relationship, Drug Female Humans Male Piperazines Prolactin Psychiatric Status Rating Scales Quinolones Severity of Illness Index Tics Tourette Syndrome Treatment Outcome Young Adult |
| Subjects: | diseases & disorders > mental disorders |
| CSHL Authors: | |
| Communities: | CSHL labs > Lyon lab |
| Depositing User: | Matt Covey |
| Date: | 2009 |
| Date Deposited: | 10 Dec 2012 20:14 |
| Last Modified: | 10 Dec 2012 21:11 |
| PMCID: | PMC2861961 |
| URI: | https://repository.cshl.edu/id/eprint/26293 |
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