Alteration of four identified K+ currents in Drosophila muscle by mutations in eag

Zhong, Y., Wu, C. F. (June 1991) Alteration of four identified K+ currents in Drosophila muscle by mutations in eag. Science, 252 (5012). pp. 1562-4. ISSN 0036-8075 (Print)



Voltage-clamp analysis of Drosophila larval muscle revealed that ether a go-go (eag) mutations affected all identified potassium currents, including those specifically eliminated by mutations in the Shaker or slowpoke gene. Together with DNA sequence analysis, the results suggest that the eag locus encodes a subunit common to different potassium channels. Thus, combinatorial assembly of polypeptides from different genes may contribute to potassium channel diversity.

Item Type: Paper
Additional Information:
Uncontrolled Keywords: 4-Aminopyridine pharmacology Animals Calcium pharmacology Chromosome Mapping Drosophila genetics physiology Electric Stimulation Kinetics Larva Membrane Potentials drug effects Muscles physiology Mutation Potassium Channels drug effects genetics physiology Quinidine pharmacology
Subjects: organism description > animal > insect > Drosophila
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Zhong lab
Depositing User: CSHL Librarian
Date: 14 June 1991
Date Deposited: 30 Mar 2012 18:07
Last Modified: 30 Mar 2012 18:07

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