Neural substrates of memory: From synapse to system

Dubnau, J. T., Chiang, A. S., Tully, T. (January 2003) Neural substrates of memory: From synapse to system. Journal of Neurobiology, 54 (1). pp. 238-253. ISSN 0022-3034

DOI: 10.1002/neu.10170


One of the fundamental challenges of modern neuroscience is to understand how memories are acquired, stored, and retrieved by the brain. In the broadest terms, attempts to dissect memory can be broken down into four experimental disciplines: (1) identification of molecular components, (2) ex vivo and in vivo cellular analysis of neuronal function, (3) theoretical modeling approaches of neural systems, and (4) organismal-level behavioral analyses. Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila. (C) 2003 Wiley Periodicals, Inc.

Item Type: Paper
Uncontrolled Keywords: NEURAL SUBSTRATES Neural substrates MEMORY Memory THEORETICAL MODELING Theoretical modeling BEHAVIORAL ANALYSES Behavioral analyses LONG TERM POTENTIATION Long term potentiation DROSOPHILA MUSHROOM BODY Drosophila mushroom body ELEMENT BINDING Element binding PROTEIN Protein ASPARTATE RECEPTOR ANTAGONIST Aspartate receptor antagonist CAMP RESPONSIVE ELEMENT Camp responsive element APLYSIA SENSORY NEURONS Aplysia sensory neurons OLFACTORY MEMORY Olfactory memory GENETIC DISSECTION Genetic dissection LASTING Lasting POTENTIATION Potentiation SELECTIVE IMPAIRMENT Selective impairment
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Dubnau lab
CSHL labs > Tully lab
Depositing User: Brian Soldo
Date: January 2003
Date Deposited: 23 Mar 2012 14:10
Last Modified: 09 Apr 2013 16:12
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