Ethanol sensitivity and tolerance in long-term memory mutants of Drosophila melanogaster

Berger, K. H., Kong, E. C., Dubnau, J. T., Tully, T., Moore, M. S., Heberlein, U. (May 2008) Ethanol sensitivity and tolerance in long-term memory mutants of Drosophila melanogaster. Alcoholism-Clinical and Experimental Research, 32 (5). pp. 895-908. ISSN 0145-6008

DOI: 10.1111/j.1530-0277.2008.00659.x


Background: It has become increasingly clear that molecular and neural mechanisms underlying learning and memory and drug addiction are largely shared. To confirm and extend these findings, we analyzed ethanol-responsive behaviors of a collection of Drosophila long-term memory mutants. Methods: For each mutant, sensitivity to the acute uncoordinating effects of ethanol was quantified using the inebriometer. Additionally, 2 distinct forms of ethanol tolerance were measured: rapid tolerance, which develops in response to a single brief exposure to a high concentration of ethanol vapor; and chronic tolerance, which develops following a sustained low-level exposure. Results: Several mutants were identified with altered sensitivity, rapid or chronic tolerance, while a number of mutants exhibited multiple defects. Conclusions: The corresponding genes in these mutants represent areas of potential overlap between learning and memory and behavioral responses to alcohol. These genes also define components shared between different ethanol behavioral responses.

Item Type: Paper
Uncontrolled Keywords: alcohol sensitivity tolerance Drosophila learning memory PHARMACOLOGICAL EVIDENCE Pharmacological evidence TRANSLATIONAL REGULATION Translational regulation INTOXICATED Intoxicated PRACTICE Practice SYNAPTIC PLASTICITY Synaptic plasticity ALCOHOL SENSITIVITY Alcohol sensitivity SIGNALING PATHWAY Signaling pathway MODIFIER SUBUNIT Modifier subunit MOTOR IMPAIRMENT Motor impairment RAPID TOLERANCE Rapid tolerance LOW LEVEL Low level
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > addiction
organism description > animal behavior > learning
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Dubnau lab
Depositing User: Brian Soldo
Date: May 2008
Date Deposited: 23 Mar 2012 13:47
Last Modified: 22 Dec 2023 17:33
PMCID: PMC3044939
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