Ode to the mushroom bodies

Dubnau, J. T. (February 2012) Ode to the mushroom bodies. Science, 335 (6069). pp. 664-5. ISSN 1095-9203 (Electronic) 0036-8075 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22323806
DOI: 10.1126/science.1218171


Immediately after a behavioral experience, our memories are rich and vibrant but fragile. Over time, memory of an event or experience begins to fade, but we typically remember the important details because memories become consolidated into a form that is resistant to the passage of time and disruption. Invertebrate animal models, including the fruit fly Drosophila melanogaster, have been used to elucidate mechanisms of consolidation that rely on biochemical signaling within a neuron (1, 2). By contrast, most investigations of communication between brain regions for systems-level consolidation have focused on vertebrate animals, based on the assumption that larger, more complex brains are capable of more elaborate processing of memory over time (3, 4). However, several recent studies have provoked a systems view of fruit fly memory (5–7), and on page 678 of this issue, Chen et al. (8) provide an even stronger push in that direction.

Item Type: Paper
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body
CSHL Authors:
Communities: CSHL labs > Dubnau lab
Highlight: Dubnau, Josh T.
Depositing User: Brian Soldo
Date: 10 February 2012
Date Deposited: 22 Mar 2012 17:00
Last Modified: 03 Apr 2015 18:48
Related URLs:
URI: https://repository.cshl.edu/id/eprint/25407

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