Basal forebrain cholinergic modulation of auditory activity in the zebra finch song system

Shea, S. D., Margoliash, D. (2003) Basal forebrain cholinergic modulation of auditory activity in the zebra finch song system. Neuron, 40 (6). pp. 1213-1226. ISSN 08966273 (ISSN)

DOI: 10.1016/s0896-6273(03)00723-2


The cholinergic basis of auditory "gating" in the sensorimotor nucleus HVc and its efferent target robustus archistriatalis (RA) was investigated in anesthetized zebra finches. Injections of cholinergic agonists carbachol or muscarine into HVc strongly affected discharge rates and diminished auditory responsiveness in both HVc and its target RA, changes toward an awake-like condition. HVc nicotine injections produced similar strong effects in HVc, but weaker and inconsistent effects in RA. Stimulation of basal forebrain (BF) produced an initial transient network shutdown followed by diminished auditory responsiveness in HVc and RA. All stimulation effects were blocked when preceded by HVc injections of nicotinic or muscarinic antagonists. Thus, BF cholinergic modulation of song system auditory activity acting via functionally distinct HVc circuits can contribute to auditory gating. We hypothesize that wakeful BF activity levels block sensory input to motor systems and adaptively change during behavior to allow sensorimotor feedback such as auditory feedback during singing.

Item Type: Paper
Additional Information:
Uncontrolled Keywords: carbachol muscarine nicotine animal experiment article auditory response cholinergic system feedback system forebrain motor system nerve stimulation nonhuman priority journal regulatory mechanism sensorimotor cortex sensory stimulation singing songbird Acoustic Stimulation Action Potentials Animals Auditory Pathways Cholinergic Agonists Cholinergic Fibers Prosencephalon Songbirds songbirds Vocalization Animal
Subjects: organism description > animal behavior > auditory
organism description > animal > bird
organs, tissues, organelles, cell types and functions > tissues types and functions > forebrain
CSHL Authors:
Communities: CSHL labs > Shea lab
Depositing User: Leigh Johnson
Date: 2003
Date Deposited: 07 Mar 2012 19:30
Last Modified: 10 Feb 2017 22:04
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