SV40 DNA Replication

Melendy, T., Stillman, B. (1992) SV40 DNA Replication. In: Nucleic Acids Research. Oxford Academic, pp. 129-158.

DOI: 10.1007/978-3-642-77356-3_8


Just as some of the pioneers of molecular biology turned to bacteriophages because of their relative simplicity (Cairns et al. 1966), investigations into the molecular biology of eukaryotes has often relied on studies of viruses. One of these viruses, Simian Virus 40, (SV40) has been the focus of many seminal studies. The virus, tumorigenic in nonpermissive rodent cells, was crucial in the early studies of oncogenic transformation. Because the virus is permissive in both simian and human cells, it has become a superb tool for investigating human cell biology. Biological questions as diverse as intracellular targeting, transcription, and transformation have all taken advantage of studies on SV40. Similarly, research on human DNA replication has benefited greatly by using the SV40 system as a tool. SV40 has the additional property that its DNA is assembled into chromatin in a way similar to human chromosomal DNA. Hence, the system can be used to study not only DNA replication but also the concomitant process of chromatin assembly.

Item Type: Book Section
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
organism description > virus
CSHL Authors:
Communities: CSHL labs > Stillman lab
Highlight: Stillman, Bruce W.
Depositing User: CSHL Librarian
Date: 1992
Date Deposited: 02 Mar 2012 19:35
Last Modified: 04 Nov 2019 16:43

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving