Austin, C. P., Battey, J. F., Bradley, A., Bucan, M., Capecchi, M., Collins, F. S., Dove, W. F., Duyk, G., Dymecki, S., Eppig, J. T., Grieder, F. B., Heintz, N., Hicks, G., Insel, T. R., Joyner, A., Koller, B. H., Lloyd, K. C. K., Magnuson, T., Moore, M. W., Nagy, A., Pollock, J. D., Roses, A. D., Sands, A. T., Seed, B., Skarnes, W. C., Snoddy, J., Soriano, P., Stewart, D. J., Stewart, F., Stillman, B., Varmus, H., Varticovski, L., Verma, I. M., Vogt, T. F., von Melchner, H., Witkowski, J., Woychik, R. P., Wurst, W., Yancopoulos, G. D., Young, S. G., Zambrowicz, B. (September 2004) The knockout mouse project. Nature Genetics, 36 (9). pp. 921-924. ISSN 1061-4036
Abstract
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | EMBRYONIC STEM-CELLS embryonic stem cells GENE-TRAP MUTAGENESIS gene trap mutagenesis HUMAN GENOME human genome MICE mouse mice SEQUENCE sequence IDENTIFICATION identification DEFICIENCY deficiency PHENOTYPE phenotype RESOURCE resource INSIGHTS insights |
| Subjects: | bioinformatics > genomics and proteomics > databases > database construction bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL labs > Stillman lab |
| Highlight: | Stillman, Bruce W. |
| Depositing User: | CSHL Librarian |
| Date: | September 2004 |
| Date Deposited: | 07 Mar 2012 18:59 |
| Last Modified: | 20 Jun 2017 18:15 |
| PMCID: | PMC2716027 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/24933 |
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