Kuhlman, S. J. (2007) Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function. Cold Spring Harbor Symposia on Quantitative Biology, 72. pp. 21-33. ISSN 00917451 (ISSN)
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Abstract
Pacemakers are functional units capable of generating oscillations that synchronize downstream rhythms. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is a circadian pacemaker composed of individual neurons that intrinsically express a near 24-hour rhythm in gene expression. Rhythmic gene expression is tightly coupled to a rhythm in spontaneous firing rate via intrinsic daily regulation of potassium current. Recent progress in the field indicates that SCN pacemaking is a specialized property that emerges from intrinsic features of single cells, structural connectivity among cells, and activity dynamics within the SCN. The focus of this chapter is on how Nature built a functional pacemaker from many individual oscillators that is capable of coordinating the daily timing of essential brain and physiological processes.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus |
| CSHL Authors: | |
| Communities: | CSHL labs > Huang lab |
| Depositing User: | CSHL Librarian |
| Date: | 2007 |
| Date Deposited: | 14 Nov 2011 16:51 |
| Last Modified: | 30 Mar 2018 15:09 |
| URI: | https://repository.cshl.edu/id/eprint/23073 |
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