Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas

Sivertsen, E. A., Galteland, E., Mu, D., Holte, H., Meza-Zepeda, L., Myklebost, O., Patzke, S., Smeland, E. B., Stokke, T. (January 2006) Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas. Leukemia, 20 (3). pp. 539-542. ISSN 08876924

DOI: 10.1038/sj.leu.2404094


Gains and losses of genomic material are changes that play central roles in tumor development and progression. Comparative genomic hybridization (CGH) allows for the detection of over- and underrepresented sequences in tumor DNA as compared to normal DNA, and such genomic aberrations have been shown to have prognostic value in several studies of primary lymphomas. The serine/threonine kinase PIM1 is a known oncogene that has previously been shown to be upregulated in prostate cancer. Overexpression of PIM1 in cell lines protects against apoptosis induced by genotoxic agents. The PIM1 gene is localized to chromosome 6p21.2. Parts of chromosome 6 or the whole 6p arm are gained in a subset of B-cell non-Hodgkin's lymphomas, and these gains are associated with a poor prognosis.1

Item Type: Paper
Subjects: Investigative techniques and equipment > comparative genomic hybridization
Investigative techniques and equipment > assays > comparative genomic hybridization
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
diseases & disorders > cancer > cancer types > lymphoma
CSHL Authors:
Communities: CSHL labs > Powers lab
Depositing User: CSHL Librarian
Date: 26 January 2006
Date Deposited: 09 Dec 2011 16:17
Last Modified: 27 Apr 2018 16:56
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