Kopec, C. D., Malinow, R.
(December 2006)
Neuroscience. Matters of size.
Science, 314 (5805).
pp. 1554-5.
ISSN 1095-9203 (Electronic)
Abstract
From the overall body plan of an organism to the intricate three-dimensional fold of proteins, structure is a key determinant of function. Neurons, the fundamental cells of the nervous system, are no exception. The architecture of their dendritic and axonal arbors—the cellular extensions that receive and transmit information—determines which neurons they can connect to, whereas the diameter of these extensions determines the speed and filtering of electrical signals that travel down them. Tiny femtoliter (10−15 liter)-sized protrusions from neuronal dendrites, called spines, receive a functional connection from another neuron's axon at a specialized area of contact known as a synapse. A study by Park et al. in a recent issue of Neuron (1) marks a large step forward in our understanding of how spine size and synaptic strength are balanced.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Actins metabolism
Animals
Dendrites physiology ultrastructure
Dendritic Spines physiology ultrastructure
Endosomes metabolism
Exocytosis
Lipid Metabolism
Long-Term Potentiation
Microfilaments physiology
Microscopy Electron
Microscopy Fluorescence
Models Neurological
Neurons physiology ultrastructure
Receptors AMPA metabolism
Synapses physiology
Synaptic Transmission |
| Subjects: |
bioinformatics > genomics and proteomics > design > protein design
organs, tissues, organelles, cell types and functions > tissues types and functions > axon
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Malinow lab
School of Biological Sciences > Publications |
| Depositing User: |
CSHL Librarian
|
| Date: |
8 December 2006 |
| Date Deposited: |
13 Dec 2011 16:56 |
| Last Modified: |
19 Sep 2014 18:45 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/22845 |
Actions (login required)
 |
Administrator's edit/view item |
