Huang, Z. J.
(February 2006)
Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules.
Nat Neurosci, 9 (2).
pp. 163-166.
Abstract
In vertebrate nervous systems, different classes of synaptic inputs are often segregated into restricted compartments of target neurons. For example, distinct types of GABAergic interneurons preferentially innervate subcellular domains and have been implicated in the precise temporal regulation of integration within neurons and activity within networks. Recent studies suggest that the subcellular segregation of different classes of GABAergic synapses is largely genetically determined. The localization and signaling of L1 family immunoglobulin proteins recruited by ankyrin-based membrane adaptors might serve as compartmental labels, which contribute to subcellular synapse organization in cerebellar Purkinje neurons.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Animals
Ankyrins metabolism
Models Neurological
Neural Cell Adhesion Molecule L1/ metabolism
Purkinje Cells metabolism
ultrastructure
Research Support, N.I.H.
Extramural
Research Support
Non-U.S. Gov't
Synapses
metabolism
ultrastructure
gamma-Aminobutyric Acid
metabolism |
| Subjects: |
bioinformatics > genomics and proteomics > small molecules > GABAergic
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > immunoglobulin proteins
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Huang lab |
| Depositing User: |
CSHL Librarian
|
| Date: |
February 2006 |
| Date Deposited: |
14 Dec 2011 15:24 |
| Last Modified: |
01 Mar 2013 14:59 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/22826 |
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