Xuan, Z., Zhang, M. Q. (January 2005) From worm to human: bioinformatics approaches to identify FOXO target genes. Mech Ageing Dev, 126 (1). pp. 209-15. ISSN 0047-6374 (Print)
Abstract
Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead transcriptional regulators. Here we demonstrate how to identify FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Computational Biology methods Forkhead Transcription Factors Gene Expression Regulation genetics/physiology Humans Nuclear Proteins genetics/metabolism Response Elements genetics Sequence Analysis, DNA methods Signal Transduction genetics physiology Transcription Factors genetics metabolism |
| Subjects: | bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > cis-regulatory elements bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhang lab |
| Depositing User: | CSHL Librarian |
| Date: | January 2005 |
| Date Deposited: | 21 Dec 2011 17:07 |
| Last Modified: | 21 Dec 2011 17:09 |
| URI: | https://repository.cshl.edu/id/eprint/22737 |
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