Replication, repair, and reactivation

Vaughn, M. W., Tanurdzic, M., Martienssen, R. (December 2005) Replication, repair, and reactivation. Dev Cell, 9 (6). pp. 724-5. ISSN 1534-5807 (Print)

DOI: 10.1016/j.devcel.2005.11.011


In a recent issue of Current Biology, Kapoor et al. (2005) and Elmayan et al. (2005) illuminate the linkage between DNA replication and repair and transcriptional gene silencing in plants by showing that mutants in RPA2, a homolog of yeast and mammalian replication protein A, exhibit loss of silencing at transgene loci as well as some transposable elements. This is accompanied by a shift in histone H3 methylation modifications at these loci from a heterochromatic to a euchromatic pattern. Intriguingly, cytosine methylation is unaffected at the reactivated loci, indicating that transmission of DNA methylation and histone modification status can be uncoupled.

Item Type: Paper
Uncontrolled Keywords: Animals Arabidopsis physiology Arabidopsis Proteins genetics DNA Repair physiology DNA Replication physiology DNA Plant physiology Gene Silencing physiology Genes Plant physiology Humans
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA methylation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein methylation
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: CSHL Librarian
Date: December 2005
Date Deposited: 05 Jan 2012 16:23
Last Modified: 09 Apr 2014 20:46
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