Hall, P. A., Lowe, S. W. (January 2005) Molecular and cellular themes in cancer research: II. Journal of Pathology, 205 (2). pp. 121-122. ISSN 0022-3417
Abstract
Contemporary cancer research encompasses a broad range of activities spanning basic molecular and cell biology, in vitro and in vivo models and clinical studies. Much current activity in cancer research endeavours to translate the former through model systems into clinical practice. The purpose of the reviews in this issue is to exemplify the strategies and approaches used in such endeavours. The first group of reviews focus on specific key molecules of interest in cancer biology including elements of the cell cycle machinery, the WNT pathway and HOX genes, as well as the epigenetic regulation of cancer critical genes. The second cohort of reviews consider novel transgenic model systems and how such models can be non-invasively imaged. The final reviews in this group consider the huge advances in our understanding of the p53 pathway and stress responses that have come from in vivo systems. Finally, the clinical relevance of these approaches is highlighted in essays on the use of gene profiling modern technologies to assess tumours of unknown origin, the molecular basis of breast cancer and gastrointestinal lymphoma, and the key area of drug resistance in cancer. These reviews highlight the multidisciplinary nature of current cancer research, which is increasingly having impact on patient care. Copyright (C) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | neoplasia WNT HOX IGFBP epigenetic animal model in vivo imaging transgenic pathway translational research |
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal |
| CSHL Authors: | |
| Communities: | CSHL labs > Lowe lab |
| Depositing User: | CSHL Librarian |
| Date: | January 2005 |
| Date Deposited: | 13 Jan 2012 15:16 |
| Last Modified: | 03 May 2018 19:39 |
| URI: | https://repository.cshl.edu/id/eprint/22585 |
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