AMPA receptor phosphorylation during synaptic plasticity

Boehm, J., Malinow, R. (December 2005) AMPA receptor phosphorylation during synaptic plasticity. Biochem Soc Trans, 33 (Pt 6). pp. 1354-6. ISSN 0300-5127 (Print)

DOI: 10.1042/bst20051354


A widely studied example of vertebrate plasticity is LTP (long-term potentiation), the persistent synaptic enhancement that follows a brief period of coinciding pre- and post-synaptic activity. During LTP, different kinases, including CaMKII (calcium/calmodulin-dependent protein kinase II) and protein kinase A, become activated and play critical roles in induction and maintenance of enhanced transmission. Biochemical analyses have revealed several regulated phosphorylation sites in the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor subunits, GluR1 and GluR4. The regulated insertion of these receptors is a key event in the induction of LTP. Here, we discuss the phosphorylation of GluR1 and GluR4 and its role in receptor delivery and neuronal plasticity.

Item Type: Paper
Uncontrolled Keywords: Animals Ca(2+)-Calmodulin Dependent Protein Kinase metabolism Cyclic AMP-Dependent Protein Kinases/metabolism Long-Term Potentiation physiology Phosphorylation Receptors AMPA metabolism Synapses metabolism long-term potentiation
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: CSHL Librarian
Date: December 2005
Date Deposited: 17 Jan 2012 16:37
Last Modified: 02 May 2018 19:04
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