Induction of complete regressions of oncogene-induced breast tumors in mice

Benezra, R., Henke, E., Ciarrocchi, A., Ruzinova, M., Solit, D., Rosen, N., Nolan, Daniel, Mittal, V., De Candia, P. (2005) Induction of complete regressions of oncogene-induced breast tumors in mice. Cold Spring Harbor Symposia on Quantitative Biology, 70 (1). pp. 375-381. ISSN 00917451 (ISSN)

DOI: 10.1101/sqb.2005.70.006


Over the past decade, mouse models of cancer have come to resemble human disease much more closely than simple subcutaneousor orthotopic systems. Intervention strategies that work on these new model systems are more likely to have an impactclinically. We have shown recently that antiangiogenic stress imposed by loss of Id protein in endothelial progenitor cellsresults in dramatic central necrosis in breast tumors initiated in mice by overexpression of the her2/neu oncogene. Tumor cellsremain viable at the periphery, perhaps via the hypoxic response pathway which allows the lesions to expand. Inhibition ofthis pathway by the inactivation of the Hif-1α chaperone Hsp90 in combination with antiangiogenic stress leads to the firstreported complete regression of these aggressive breast tumors.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > breast cancer
CSHL Authors:
Communities: CSHL labs > Mittal lab
Depositing User: CSHL Librarian
Date: 2005
Date Deposited: 17 Jan 2012 16:33
Last Modified: 02 May 2018 18:58
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