Svitkina, T., Lin, W. H., Webb, D. J., Yasuda, R., Wayman, G. A., Van Aelst, L., Soderling, S. H. (November 2010) Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity, and Disorders. J Neurosci, 30 (45). pp. 14937-14942. ISSN 1529-2401 (Electronic) 0270-6474 (Linking)
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Abstract
The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during experience-dependent plasticity. This mini-symposium review will feature ongoing research into how spines are regulated by actin-signaling pathways during development and plasticity. It will also highlight evolving studies into how disruptions to these pathways might be functionally coupled to congenital disorders such as mental retardation.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > congenital hereditary genetic diseases organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons |
| CSHL Authors: | |
| Depositing User: | CSHL Librarian |
| Date: | 10 November 2010 |
| Date Deposited: | 19 Oct 2011 14:08 |
| Last Modified: | 22 Feb 2017 16:07 |
| PMCID: | PMC3074493 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15536 |
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