Tracing the tumor lineage

Navin, N. E., Hicks, J. B. (May 2010) Tracing the tumor lineage. Molecular Oncology. ISSN 1878-0261 (Electronic) 1574-7891 (Linking)

DOI: 10.1016/j.molonc.2010.04.010


Defining the pathways through which tumors progress is critical to our understanding and treatment of cancer. We do not routinely sample patients at multiple time points during the progression of their disease, and thus our research is limited to inferring progression a posteriori from the examination of a single tumor sample. Despite this limitation, inferring progression is possible because the tumor genome contains a natural history of the mutations that occur during the formation of the tumor mass. There are two approaches to reconstructing a lineage of progression: (1) inter-tumor comparisons, and (2) intra-tumor comparisons. The inter-tumor approach consists of taking single samples from large collections of tumors and comparing the complexity of the genomes to identify early and late mutations. The intra-tumor approach involves taking multiple samples from individual heterogeneous tumors to compare divergent clones and reconstruct a phylogenetic lineage. Here we discuss how these approaches can be used to interpret the current models for tumor progression. We also compare data from primary and metastatic copy number profiles to shed light on the final steps of breast cancer progression. Finally, we discuss how recent technical advances in single cell genomics will herald a new era in understanding the fundamental basis of tumor heterogeneity and progression.

Item Type: Paper
Uncontrolled Keywords: Cancer phylogenetics CGH microarrays Copy number aberrations Tumor heterogeneity Tumor progression
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > analysis and processing > microarray gene expression processing
CSHL Authors:
Communities: CSHL labs > Wigler lab
School of Biological Sciences > Publications
Depositing User: CSHL Librarian
Date: 5 May 2010
Date Deposited: 05 Oct 2011 15:11
Last Modified: 07 Jan 2019 16:53
PMCID: PMC2904844
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