Reactome: a knowledge base of biologic pathways and processes

Vastrik, I., D'Eustachio, P., Schmidt, E., Joshi-Tope, G., Gopinath, G., Croft, D., de Bono, B., Gillespie, M., Jassal, B., Lewis, S., Matthews, L., Wu, G., Birney, E., Stein, L. D. (2007) Reactome: a knowledge base of biologic pathways and processes. Genome Biol, 8 (3). R39. ISSN 1474-760X

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URL: https://www.ncbi.nlm.nih.gov/pubmed/17367534

DOI: 10.1186/gb-2007-8-3-r39

Abstract

Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.

Item Type:	Paper
Uncontrolled Keywords:	INSULIN-RESISTANT SYSTEMS BIOLOGY DATABASE PROTEIN NETWORK MODELS GENES INFORMATION BIND TOOL
Subjects:	bioinformatics > genomics and proteomics > databases > database optimization bioinformatics > genomics and proteomics > databases bioinformatics > quantitative biology bioinformatics > genomics and proteomics > computers > computer software
CSHL Authors:	D’Eustachio, Peter Gillespie, Marc Gopinath, Gopal Joshi-Tope, Geeta Matthews, Lisa Stein, Lincoln D. Wu, Guanming
Communities:	CSHL labs > Stein lab
Depositing User:	CSHL Librarian
Date:	2007
Date Deposited:	02 Sep 2011 20:16
Last Modified:	10 Apr 2018 20:33
PMCID:	PMC1868929
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/15270

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