A transient postnatal quiescent period precedes emergence of mature cortical dynamics.

Domínguez, Soledad, Ma, Liang, Yu, Han, Pouchelon, Gabrielle, Mayer, Christian, Spyropoulos, George D, Cea, Claudia, Buzsáki, György, Fishell, Gordon, Khodagholy, Dion, Gelinas, Jennifer N (July 2021) A transient postnatal quiescent period precedes emergence of mature cortical dynamics. eLife, 10. ISSN 2050-084X

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URL: https://www.ncbi.nlm.nih.gov/pubmed/34296997
DOI: 10.7554/eLife.69011

Abstract

Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these activity patterns and functions is believed to be developmentally regulated, but the postnatal time course for neural networks to perform complex computations remains unknown. We investigate the progression of large-scale synaptic and cellular activity patterns across development using high spatiotemporal resolution in vivo electrophysiology in immature mice. We reveal that mature cortical processes emerge rapidly and simultaneously after a discrete but volatile transition period at the beginning of the second postnatal week of rodent development. The transition is characterized by relative neural quiescence, after which spatially distributed, temporally precise, and internally organized activity occurs. We demonstrate a similar developmental trajectory in humans, suggesting an evolutionarily conserved mechanism that could facilitate a transition in network operation. We hypothesize that this transient quiescent period is a requisite for the subsequent emergence of coordinated cortical networks.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organism description > animal > developmental stage
organism description > animal > mammal > primates > hominids > human
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs > Pouchelon lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 23 July 2021
Date Deposited: 07 Dec 2021 15:21
Last Modified: 07 Dec 2021 15:21
PMCID: PMC8357419
URI: https://repository.cshl.edu/id/eprint/40445

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