The organization and development of cortical interneuron presynaptic circuits are area specific.

Pouchelon, Gabrielle, Dwivedi, Deepanjali, Bollmann, Yannick, Agba, Chimuanya K, Xu, Qing, Mirow, Andrea MC, Kim, Sehyun, Qiu, Yanjie, Sevier, Elaine, Ritola, Kimberly D, Cossart, Rosa, Fishell, Gord (November 2021) The organization and development of cortical interneuron presynaptic circuits are area specific. Cell Reports, 37 (6). p. 109993. ISSN 2211-1247

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Abstract

Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory and cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant and are thought to form canonical circuits regardless of which area they are embedded in. Here, we investigate whether this is achieved through selective and systematic variations in their afferent connectivity during development. To this end, we examined the development of their inputs within distinct cortical areas. We find that interneuron afferents show little evidence of being globally stereotyped. Rather, each subtype displays characteristic regional connectivity and distinct developmental dynamics by which this connectivity is achieved. Moreover, afferents dynamically regulated during development are disrupted by early sensory deprivation and in a model of fragile X syndrome. These data provide a comprehensive map of interneuron afferents across cortical areas and reveal the logic by which these circuits are established during development.

Item Type:	Paper
Subjects:	diseases & disorders > congenital hereditary genetic diseases diseases & disorders organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex diseases & disorders > congenital hereditary genetic diseases > fragile X syndrome organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions > somatosensory cortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types > somatostatin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > somatostatin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > somatostatin neurons organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Pouchelon, Gabrielle
Communities:	CSHL labs > Pouchelon lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	9 November 2021
Date Deposited:	18 Nov 2021 16:28
Last Modified:	25 Jan 2024 16:19
PMCID:	PMC8832360
URI:	https://repository.cshl.edu/id/eprint/40428

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