Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland.

Zhu, Xiaoyan, Tollkuhn, Jessica, Taylor, Havilah, Rosenfeld, Michael G (December 2015) Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland. Stem Cell Reports, 5 (6). pp. 1196-1209. ISSN 2213-6711

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Abstract

Although SOX2(+) stem cells are present in the postnatal pituitary gland, how they are regulated molecularly and whether they are required for pituitary functions remain unresolved questions. Using a conditional knockout animal model, here we demonstrate that ablation of the canonical Notch signaling in the embryonic pituitary gland leads to progressive depletion of the SOX2(+) stem cells and hypoplastic gland. Furthermore, we show that the SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period. However, we found that within several weeks postpartum, the SOX2(+) stem cells switch to an essentially dormant state and are no longer required for homeostasis/tissue adaptation. Our results present a dynamic tissue homeostatic model in which stem cells provide an initial contribution to the growth of the neonatal pituitary gland, whereas the mature gland can be maintained in a stem cell-independent fashion.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > tissues types and functions > pituitary gland therapies > stem cells
CSHL Authors:	Tollkuhn, Jessica
Communities:	CSHL labs > Tollkuhn lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	8 December 2015
Date Deposited:	24 May 2021 18:44
Last Modified:	24 May 2021 18:44
PMCID:	PMC4682291
URI:	https://repository.cshl.edu/id/eprint/40157

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