Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome.

Wilkinson, Michael J, Manoogian, Emily NC, Zadourian, Adena, Lo, Hannah, Fakhouri, Savannah, Shoghi, Azarin, Wang, Xinran, Fleischer, Jason G, Navlakha, Saket, Panda, Satchidananda, Taub, Pam R (January 2020) Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome. Cell Metabolism, 31 (1). 92-104.e5. ISSN 1550-4131

URL: https://www.ncbi.nlm.nih.gov/pubmed/31813824
DOI: 10.1016/j.cmet.2019.11.004

Abstract

In animal models, time-restricted feeding (TRF) can prevent and reverse aspects of metabolic diseases. Time-restricted eating (TRE) in human pilot studies reduces the risks of metabolic diseases in otherwise healthy individuals. However, patients with diagnosed metabolic syndrome often undergo pharmacotherapy, and it has never been tested whether TRE can act synergistically with pharmacotherapy in animal models or humans. In a single-arm, paired-sample trial, 19 participants with metabolic syndrome and a baseline mean daily eating window of ≥14 h, the majority of whom were on a statin and/or antihypertensive therapy, underwent 10 h of TRE (all dietary intake within a consistent self-selected 10 h window) for 12 weeks. We found this TRE intervention improves cardiometabolic health for patients with metabolic syndrome receiving standard medical care including high rates of statin and anti-hypertensive use. TRE is a potentially powerful lifestyle intervention that can be added to standard medical practice to treat metabolic syndrome. VIDEO ABSTRACT.

Item Type: Paper
Subjects: diseases & disorders > nutritional and metabolic diseases
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
CSHL Authors:
Communities: CSHL labs > Navlakha lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 7 January 2020
Date Deposited: 07 May 2021 15:40
Last Modified: 07 May 2021 15:40
PMCID: PMC6953486
URI: https://repository.cshl.edu/id/eprint/40049

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