The molecular basis of mammary gland development and epithelial differentiation

Slepicka, P. F., Somasundara, A. V. H., Dos Santos, C. O. (October 2020) The molecular basis of mammary gland development and epithelial differentiation. Semin Cell Dev Biol. ISSN 1084-9521

DOI: 10.1016/j.semcdb.2020.09.014


Our understanding of the molecular events underpinning the development of mammalian organ systems has been increasing rapidly in recent years. With the advent of new and improved next-generation sequencing methods, we are now able to dig deeper than ever before into the genomic and epigenomic events that play critical roles in determining the fates of stem and progenitor cells during the development of an embryo into an adult. In this review, we detail and discuss the genes and pathways that are involved in mammary gland development, from embryogenesis, through maturation into an adult gland, to the role of pregnancy signals in directing the terminal maturation of the mammary gland into a milk producing organ that can nurture the offspring. We also provide an overview of the latest research in the single-cell genomics of mammary gland development, which may help us to understand the lineage commitment of mammary stem cells (MaSCs) into luminal or basal epithelial cells that constitute the mammary gland. Finally, we summarize the use of 3D organoid cultures as a model system to study the molecular events during mammary gland development. Our increased investigation of the molecular requirements for normal mammary gland development will advance the discovery of targets to predict breast cancer risk and the development of new breast cancer therapies.

Item Type: Paper
Additional Information: 1096-3634 Slepicka, Priscila Ferreira Somasundara, Amritha Varshini Hanasoge Dos Santos, Camila O Journal Article Review England Semin Cell Dev Biol. 2020 Oct 17:S1084-9521(20)30161-0. doi: 10.1016/j.semcdb.2020.09.014.
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > breast
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > differentiation
CSHL Authors:
Communities: CSHL labs > Dos Santos lab
Depositing User: Matthew Dunn
Date: 17 October 2020
Date Deposited: 11 Jan 2021 16:04
Last Modified: 29 Jun 2021 17:45
PMCID: PMC8052380
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