Long-range interactions between short axon cells and external tufted cells gate glomerular output in the mouse olfactory bulb.

Banerjee, Arkarup, Marbach, F., Anselmi, Francesca, Koh, Matthew S, Davis, Martin B, Garcia da Silva, P., Delevich, K., Oyibo, Hassana K., Gupta, Priyanka, Li, Bo, Albeanu, Dinu F (July 2017) Long-range interactions between short axon cells and external tufted cells gate glomerular output in the mouse olfactory bulb. Neuron, 87 (1). pp. 193-207. ISSN 0896-6273

URL: https://pubmed.ncbi.nlm.nih.gov/26139373/
DOI: 10.1016/j.neuron.2015.06.019

Abstract

Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between co-active glomeruli has been proposed to perform a variety of computations, facilitating efficient extraction of sensory information by the cortex. Dopaminergic/GABAergic cells in the OB, which can be identified by their expression of the dopamine transporter (DAT), provide the earliest opportunity for such crosstalk. Here we show in mice that DAT+ cells carry concentration-dependent odor signals and broadcast focal glomerular inputs throughout the OB to cause suppression of mitral/tufted (M/T) cell firing, an effect that is mediated by the external tufted (ET) cells coupled to DAT+ cells via chemical and electrical synapses. We find that DAT+ cells implement gain control and decorrelate odor representations in the M/T cell population. Our results further indicate that ET cells are gatekeepers of glomerular output and prime determinants of M/T responsiveness.

Item Type: Paper
CSHL Authors:
Communities: CSHL labs > Albeanu lab
CSHL labs > Banerjee lab
Depositing User: Matthew Dunn
Date: 1 July 2017
Date Deposited: 30 Nov 2020 21:19
Last Modified: 30 Nov 2020 21:19
PMCID: PMC4633092
Related URLs:
URI: https://repository.cshl.edu/id/eprint/39827

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