Hypocretin as a Hub for Arousal and Motivation

Tyree, S. M., Borniger, J. C., de Lecea, L. (2018) Hypocretin as a Hub for Arousal and Motivation. Front Neurol, 9. p. 413. ISSN 1664-2295 (Print)1664-2295 (Linking)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/29928253
DOI: 10.3389/fneur.2018.00413

Abstract

The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated behavior. Within these populations, the hypocretin/orexin neurons are among the most well studied. Here, we provide an overview on how these neurons act as a central hub integrating sensory and physiological information to tune arousal and motivated behavior accordingly. We give special attention to their role in sleep-wake states and conditions of hyper-arousal, as is the case with stress-induced anxiety. We further discuss their roles in feeding, drug-seeking, and sexual behavior, which are all dependent on the motivational state of the animal. We further emphasize the application of powerful techniques, such as optogenetics, chemogenetics, and fiber photometry, to delineate the role these neurons play in lateral hypothalamic functions.

Item Type: Paper
Subjects: diseases & disorders > mental disorders > anxiety disorders
organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus
organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
CSHL Authors:
Communities: CSHL labs > Borniger lab
Depositing User: Adrian Gomez
Date: 2018
Date Deposited: 06 Jan 2020 14:52
Last Modified: 06 Jan 2020 14:52
PMCID: PMC5997825
URI: https://repository.cshl.edu/id/eprint/38855

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