Molecular Mechanisms of Cancer-Induced Sleep Disruption

Walker, W. H., Borniger, J. C. (June 2019) Molecular Mechanisms of Cancer-Induced Sleep Disruption. Int J Mol Sci, 20 (11). ISSN 1422-0067

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URL: https://www.ncbi.nlm.nih.gov/pubmed/31174326
DOI: 10.3390/ijms20112780

Abstract

Sleep is essential for health. Indeed, poor sleep is consistently linked to the development of systemic disease, including depression, metabolic syndrome, and cognitive impairments. Further evidence has accumulated suggesting the role of sleep in cancer initiation and progression (primarily breast cancer). Indeed, patients with cancer and cancer survivors frequently experience poor sleep, manifesting as insomnia, circadian misalignment, hypersomnia, somnolence syndrome, hot flushes, and nightmares. These problems are associated with a reduction in the patients' quality of life and increased mortality. Due to the heterogeneity among cancers, treatment regimens, patient populations and lifestyle factors, the etiology of cancer-induced sleep disruption is largely unknown. Here, we discuss recent advances in understanding the pathways linking cancer and the brain and how this leads to altered sleep patterns. We describe a conceptual framework where tumors disrupt normal homeostatic processes, resulting in aberrant changes in physiology and behavior that are detrimental to health. Finally, we discuss how this knowledge can be leveraged to develop novel therapeutic approaches for cancer-associated sleep disruption, with special emphasis on host-tumor interactions.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders > mental disorders > sleep disorders
organs, tissues, organelles, cell types and functions > organs types and functions > brain
diseases & disorders > inflammation > cytokines
CSHL Authors:
Communities: CSHL labs > Borniger lab
Depositing User: Adrian Gomez
Date: 6 June 2019
Date Deposited: 06 Jan 2020 14:42
Last Modified: 09 Jan 2020 20:32
PMCID: PMC6600154
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38853

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